Andre Bishop is the main protagonist of Fight Night Champion. He has a rivalry with boxer Isaac Frost and his manager D.L. McQueen. Since Isaac Frost brutally knocked out Andre's brother, Raymond, he declared a revenge boxing match with Isaac Frost. Frost was knocked out and Bishop fulfilled his dream and destiny - winning the heavyweight championship of the world - originally held by Isaac Frost before Bishop beat him.
He is the playable character of the Champion Mode. The Champion Mode revolves around a storyline and plot (a new feature in the Fight Night series, introduced in Fight Night Champion). The story revolves around Andre Bishop's amateur and professional boxing career as-well as his prison sentence, which takes effect around the corruption of boxing along with a comeback story after his prison sentence.